Others

Sufficient folate levels are critical throughout our entire life. However, despite the importance of folates, the majority of the population has an insufficient folate intake. This is true even in countries with a mandatory food folate fortification with folic acid. The elderly population in particular does not reach the recommended daily intake (RDI).  

Folate deficiency is assumed to reduce the cell’s capacity for DNA synthesis and repair. Impaired DNA synthesis would become most obvious in those cells undergoing rapid division.

Metafolin^® (L-methylfolate) supplies methyl groups for the synthesis of S-adenosylmethionine (SAM), which is a methyl donor for many methyltransferase enzymes. These enzymes transfer the methyl group to a wide range of substrates as diverse as proteins, lipids, hormones, DNA, etc. The methylation cycle is involved in many important biochemical reactions.

Therefore the vitamin Metafolin^® is key in a broad set of vitamin products, supporting a wide range of usage.


Key Publications / References:

Dietary Reference Intake, Food and Nutrition Board, Inst. of Med. 2000.

Ernährungsbericht 2000 Deutschland.

CDC (2007) Folate Status in Women of Childbearing Age MMWR 55(51);1377-1380.