Selected List of Publications
Properties & Benefits
J. Scott (2001):
Methyltetrahydrofolate: The Superior Alternative to Folic acid.
Nutraceuticals in health and disease prevention, 75-90 [Krämer K, Hoppe PP and Packer L, editors].
New York: Marcel Dekker Inc.
O. Hasselwander, W. Hönlein, L. Schweillert, K. Krömer (2000):
5-Methyltetrahydrofolate: The active form of folic acid.
Functional foods 2000, Conference proceedings.
...the naturally-occurring predominant form of the folate vitamer
J. Scott (2001):
Methyltetrahydrofolate: The Superior Alternative to Folic acid.
Nutraceuticals in health and disease prevention, 75-90 [Krämer K, Hoppe PP and Packer L, editors].
New York: Marcel Dekker Inc.
O. Hasselwander, W. Hönlein, L. Schweillert, K. Krömer (2000):
5-Methyltetrahydrofolate: The active form of folic acid.
Functional foods 2000, Conference proceedings.
...a readily bioavailable folate vitamer
J. Scott (2001):
Methyltetrahydrofolate: The Superior Alternative to Folic acid.
Nutraceuticals in health and disease prevention, 75-90 [Krämer K, Hoppe PP and Packer L, editors].
New York: Marcel Dekker Inc.
O. Hasselwander, W. Hönlein, L. Schweillert, K. Krömer (2000):
5-Methyltetrahydrofolate: The active form of folic acid.
Functional foods 2000, Conference proceedings.
P. Kirke, L. Mills, A. Molloy, l. Brody, V. O'Leary, L. Daly, S. Murray, M. Conley, P. Mayne, O. Smith, J. Scott (2004): Impact of the MTHFR C677T polymorphism on risk of neutral tube defects: case-control study.
BMJ, Vol. 328, 1535-6.
L. Botto, Q. Yang (2000):
5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: A HuGE Review. American Journal of Epidermiology, Vol. 151 (9), 862-77.
E. Öhrvik et al. (2010):
Folate bioavailability from breads and a meal assessed with a human stable-isotope area under the curve and ileostomy model1-3.
Am J Clin Nutr, June 2010
...directly usable by the body, independent of genetic variants of folate metabolizing enzymes
O. Hasselwander, W. Hönlein, L. Schweillert, K. Krömer (2000):
5-Methyltetrahydrofolate: The active form of folic acid.
Functional foods 2000, Conference proceedings.
P. Kirke, L. Mills, A. Molloy, l. Brody, V. O'Leary, L. Daly, S. Murray, M. Conley, P. Mayne, O. Smith, J. Scott (2004): Impact of the MTHFR C677T polymorphism on risk of neutral tube defects: case-control study.
BMJ, Vol. 328, 1535-6.
L. Botto, Q. Yang (2000):
5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: A HuGE Review.
American Journal of Epidermiology, Vol. 151 (9), 862-77.
Y. Lamers (2006):
[6S]-5-methyltetrahydrofolate compared to folic acid supplementation: Effect on risk markers of neutral tube defects.
Cuvillier Verlag, Göttingen.
D. Smith, R. Kok, T. Teerlink, C. Jakobs, Y. Smulders (2006):
Quantitative determination of erythrocyte folate vitamer distribution by liquid chromatography-tandem mass spectrometry.
Clin Chem Lab Med, 44(4), 450-9.
...directly involved in lowering homocysteine blood levels
J. Scott (2001):
Methyltetrahydrofolate: The Superior Alternative to Folic acid.
Nutraceuticals in health and disease prevention, 75-90 [Krämer K, Hoppe PP and Packer L, editors].
New York: Marcel Dekker Inc.
O. Hasselwander, W. Hönlein, L. Schweillert, K. Krömer (2000):
5-Methyltetrahydrofolate: The active form of folic acid.
Functional foods 2000, Conference proceedings.
B. Venn, T. Green, R. Moser, J. Mckenzie, C. Skeaff, J. Mann (2002):
Increase in blood folate indices are similar in women of childbearing age supplemented with [6S]-5-methyltetrahydrofolate and folic acid.
J. Nutr. 132, 3353-55.
B. Venn, T. Green, R. Moser, J. Mann (2003):
Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study.
Am J Clin Nutr, 77, 658-62.
Y. Lamers, R. Prinz-Langenohl, R. Moser, K. Pietrzik (2004):
Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women.
Am J Clin Nutr, 79, 473-8.
...the only form of folate able to cross the blood-brain barrier
M. Levitt, P. Nixon, J. Pincus, J. Bertino (1971):
Transport characteristics of folates in cerebrospinal fluid; a study utilizing double labeled 5-methyltetrahydrofolate and 5-formyltetrahydrofolate.
The Journal of Clinical Investigation, Vol. 50, 1301-8.
P. Kirke, L. Mills, A. Molloy, l. Brody, V. O'Leary, L. Daly, S. Murray, M. Conley, P. Mayne, O. Smith, J. Scott (2004): Impact of the MTHFR C677T polymorphism on risk of neutral tube defects: case-control study.
BMJ, Vol. 328, 1535-6.
T. Bottiglieri and E. Reynolds (2000):
Folate in CSF and age.
J. Neurol. Neurosurg. Psychiatry, 69, 562 – 563
...apparently does not mask a vitamin B12-deficiency
Y. Smulders, D. Smith, R. Kok, T. Teerlink, D. Swinkels, C. Stehouwer, C. Jabobs (2005):
Cellular folate vitamer distribution during and after correction of vitamin B12 deficiency: a case for the methylfolate trap.
British J. of Haematology, 132, 623-9.
S. Gutstein, L. Bernstein, L. Levy, G. Wagner (1973):
Failure of response to N5-methyltetrahydrofolate in combined folate and B12 deficiency. Evidence in support of the “folate trap” hypothesis.
Digestive diseases, Vol. 18 (2), 142-6.
J. Scott (2001):
Methyltetrahydrofolate: The Superior Alternative to Folic acid.
Nutraceuticals in health and disease prevention, 75-90 [Krämer K, Hoppe PP and Packer L, editors].
New York: Marcel Dekker Inc.
O. Hasselwander, W. Hönlein, L. Schweillert, K. Krömer (2000):
5-Methyltetrahydrofolate: The active form of folic acid.
Functional foods 2000, Conference proceedings.
...presents no risk of an accumulation of unmodified folic acid in the body
O. Hasselwander, W. Hönlein, L. Schweillert, K. Krömer (2000):
5-Methyltetrahydrofolate: The active form of folic acid.
Functional foods 2000, Conference proceedings.
P. Kirke, L. Mills, A. Molloy, l. Brody, V. O'Leary, L. Daly, S. Murray, M. Conley, P. Mayne, O. Smith, J. Scott (2004): Impact of the MTHFR C677T polymorphism on risk of neutral tube defects: case-control study.
BMJ, Vol. 328, 1535-6.
L. Botto, Q. Yang (2000):
5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: A HuGE Review.
American Journal of Epidermiology, Vol. 151 (9), 862-77.
D. Smith, R. Kok, T. Teerlink, C. Jakobs, Y. Smulders (2006):
Quantitative determination of erythrocyte folate vitamer distribution by liquid chromatography-tandem mass spectrometry.
Clin Chem Lab Med, 44(4), 450-9.
P. Kelly, J. McPartlin, M. Goggins, D. Weir, J. Scott (1997):
Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements.
Am J Clin Nutr, 65, 1790-5.
M. Lucock (2004):
Is folic acid the ultimate functional food component for disease prevention?
BMJ, Vol. 328, 211-4.
A. Troen, B. Mitchell, B. Sorensen, M. Wener, A. Johnston, B. Wood, J. Selhub, A. McTiernan, Y. Yasui, E. Oral, J. Potter, C. Ulrich (2006):
Unmetabolized folic acid is associated with reduced natural killer cell cytotoxicity among postmenopausal women.
J Nutr, 136 (1), 189-94.
M. Sweeney, J. McPartlin, D. Weir, S. Daly, K. Pentieva, L. Daly, J. Scott (2005):
Evidence of unmetabolised folic acid in cord blood of newborn and serum of 4-day-old infants.
Br J Nutr., 94(5), 727-30.
History of Folates
L. Wills (1931):
Treatment of "pernicious anaemia of pregnancy" and "tropical anaemia".
Br Med J., 1: 1059-64.
H. Mitchell, E. Snell, R. Williams (1941):
The concentration of "folic acid".
J Am Chem Soc., 63: 2284.
Preconception & Pregnancy
Y. Lamers, R. Prinz-Langenohl, S. Brämswig, K. Pietrzik (2006):
Red blood cell folate concentrations increase more after supplementation with (6S)-5-methyltetrahydrofolate than with folic acid in women of childbearing age.
Am J Clin Nutr 2006; 84: 156-61.
F. Fruzzetti (2012):
Beyaz®: an oral contraceptive fortified with folate.
Womens Health 2012 Jan;8(1):13-9.
L. Houghton, K. Sherwood, R. Pawlosky, S. Ito, D. O'Connor (2006):
(6S)-5-Methyltetrahydrofolate is at least as effective as folic acid in preventing a decline in blood folate concentrations during lactation.
Am J Clin Nutr, 83(4), 842-50.
F. Bànhidz, A. Dakhlaoui, I. Dudás, AE. Czeizel (2011):
Birth outcomes of newborns after folic Acid supplementation in pregnant women with early and late pre-eclampsia: a population-based study.
Adv Prev Med. 2011;2011:127369.
W. Holzgreve, K. Pietrzik, B. Koletzko. C. Eckmann-Scholz (2012):
Adding Folate to the Contraceptive Pill: A new Concept for the Prevention of Neural Tube Defects.
J Matern Fetal Neonatal Med. 2012 Jan 24.
Y. Lamers (2006):
(6S)-5-methyltetrahydrofolate compared to folic acid supplementation: Effect on risk markers of neutral tube defects. Cuvillier Verlag, Göttingen.
C. Roth, P. Magnus, S. Schjølberg, et al (2011):
Folic acid supplements in pregnancy and severe language delay in children.
JAMA 2011, Oct 12;306(14):1566-73.
AE. Czeizel, I. Dudás, L. Paput, F. Bánhidy (2011):
Prevention of Neural-Tube Defects with Periconceptional Folic Acid, Methylfolate, or Multivitamins?
Ann Nutr Metab. 2011 Aug 25;58(4): 263-271.
JA. Greenberg, SJ. Bell (2011):
Multivitamin Supplementation During Pregancy: Emphasis of Folic Acid and l-Methylfolate.
Rev Obstet Gynecol. 2011;4(3-4):126-7.
Sr. Bart et al. (2011):
Folate status and homocysteine levels during a 24-week oral administration of a folate-containing oral contraceptive: a randomized, double-blind, active-controlled, parallel-group, US-based multicenter study.
Contraception 2011.
H. Bean L.J., et al (2011):
Lack of maternal folic acid supplementation is associated with heart defects in Down syndrome: A report from the National Down Syndrome Project.
Birth Defects Res A Clin Mol Teratol. 2011 Oct; 91 (10):885-93.
TN. Taylor, RA. Farkouh, JB. Graham, A. Colligs, M. Lindemann, R. Lynen, SD. Candrilli (2011):
Potential reduction in neural tube defects associated with use of Metafolin-fortified oral contraceptives in the United States.
Am J Obstet Gynecol. 2011 Jun 21.
JA. Greenberg, SJ. Bell, Y. Guan, YH. Yu (2011):
Folic Acid supplementation and pregnancy: more than just neural tube defect prevention
Rev Obstet Gynecol 2011;4(2):52-9.
R. Obeid, M. Kasoha, SH. Kirsch, W. Munz, W. Herrmann (2010):
Concentrations of unmetabolized folic acid and primary folate forms in pregnant women at delivery and in umbilical cord blood. Am J Clin Nutr. 2010 Sep 15.
K. Diefenbach, D. Trummer, F. Ebert, M. Lissy, B. Rohde, H. Blode (2010):
Changes in folate levels following a 24-week co-administration of Yasmin and levomefolate calcium 0.451 mg or folic acid 400 mcg.
Eur J Contracept Reprod Health Care, 15(Suppl 1): 158-9.
P. Kirke, L. Mills, A. Molloy, I. Brody, V. O'Leary, L. Daly, S. Murray, M. Conely, P. Mayne, O. Smith, J. Scott (2004): Impact of the MTHFR C677T polymorphism on risk of neutral tube defects: case-control study.
BMJ, Vol. 328, 1535-6.
K. Sinclair, C. Allegrucci, R. Singh, D. Gardner, S. Sebastian, J. Bispham, A. Thurston et al. (2007):
DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status.
Proc. Natl. Acad. Sci. USA, 104(49): 19351-6.
B. Venn, T. Green, R. Moser, J. McKenzie, C. Skeaff, J. Mann (2002):
Increases in blood folate indices are similar in women of childbearing age supplemented with (6S)-5-methyltetrahydrofolate and folic acid.
J Nutr., 132(11): 3353-5.
S. Brämswig, R. Prinz-Langenohl, Y. Lamers, O. Tobolski, E. Wintergerst, HK. Berthold, K. Pietrzik (2009):
Supplementation with a multivitamin containing 800 microg of folic acid shortens the time to reach the preventive red blooed cell folate concentration in healthy women.
Int. J. Vitam. Nutr. Res. 79(2): 61-70.
P. Verlinde, I. Oey, M. Hendrickx, A. Van Loey, E. Temme (2007):
L-ascorbic acid improves the serum folate response to an oral dose of (6S)-5-methyltetrahydrofolic acid in healthy men.
Eur J Clin Nutr, 62(10):1224-30.
Y. Lamers, R. Prinz-Langenohl, R. Moser, K. Pietrzik (2004):
Supplementation with (6S)-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women.
Am J Clin Nutr., 79(3): 473-8.
J. Mills, J. McPartlin, P. Kirke, Y. Lee, M. Conley, D. Weir, J. Scott (1995):
Homocysteine metabolism in pregnancies complicated by neural-tube defects.
Lancet, 345(8943): 149-51.
P. Kirke, J. Mills, A. Molloy, L. Brody, V. O'Leary, L. Daly, S. Murray, M. Conley; P. Mayne, O. Smith, J. Scott (2004):
Impact of the MTHFR C677T polymorphism on risk of neural tube defects: case-control study.
BMJ, 328(7455): 1535-6.
B. Christensen, L. Arbour, P. Tran, D. Leclerc, N. Sabbaghian, R. Platt, B. Gilfix, D. Rosenblatt, R. Gravel, P. Forbes, R. Rozen (1999):
Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects.
Am J Med Genet. 84(2): 151-7.
A. Whitehead, P. Gallagher, J. Mills, P. Kirke, H. Burke, A. Molloy, D. Weir, D. Shields, J. Scott (1995):
A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects.
QJM. 88(11): 763-6.
L. Daly, P. Kirke, A. Molloy, D. Weir, J. Scott (1995):
Folate levels and neural tube defects. Implications for prevention.
JAMA.; Dec 6; 274(21): 1698-702.
P. Kirke, A. Molloy, L. Daly, H. Burke, D. Weir, J. Scott (1993):
Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects.
Q J Med. 86(11): 703-8.
R. Berry, Z. Li, J. Erickson, S. Li, C. Moore, H. Wang, J. Mulinare, P. Zhao, L-Y. Wong, J. Gindler, S-X. Hong, A. Correa (1999):
Prevention of neural-tube defects with folic acid in China.
N Engl J Med. 341: 1485-90.
A. Czeizel, I. Dudás (1992):
Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation.
N Engl J Med. 327(26): 1832-5.
MRC Vitamin Study Research Group (1991):
Prevention of neural tube defects: results of the Medical Research Council Vitamin Study.
Lancet. 338(8760): 131-7.
C. Bower, F. Stanley (1989):
Dietary folate as a risk factor for neural-tube defects: evidence froma case-control study in Western Australia.
Med J Aust. 150: 613-19.
K. Laurence, N. James, M. Miller, G. Tennant, H. Campbell (1981):
Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects.
Br Med J., 282: 1509-11.
A. Milunsky, H. Jick, S. Jick, C. Bruell, D. MacLaughlin, K. Rothman, W. Willett (1989):
Mutivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects.
JAMA, 262: 2847-2852.
R. Smithells, N. Nevin, M. Seller, S. Sheppard, R. Harris, A. Read, D. Fielding, S. Walker, C. Schorah, J. Wild (1983):
Further experience of vitamin supplementation for prevention of neural tube defect recurrences.
Lancet, 1(8332): 1027-31.
R. Smithells, S. Sheppard, C. Schorah, M. Seller, N. Nevin, R. Harris, A. Read, D. Fielding (1980):
Possible prevention of neural-tube defects by periconceptional vitamin supplementation.
Lancet, 1(8164): 339-40.
R. Smithells, S. Sheppard, C. Schorah (1976):
Vitamin dificiencies and neural tube defects.
Arch Dis Child., 51(12): 944-50.
J. Scott (2001):
Methyltetrahydrofolate: The Superior Alternative to Folic acid.
Nutraceuticals in health and disease prevention, 75-90 [Krämer K, Hoppe PP and Packer L, editors].
New York: Marcel Dekker Inc.
O. Hasselwander, W. Hönlein, L. Schweillert, K. Krömer (2000):
5-Methyltetrahydrofolate: The active form of folic acid.
Functional foods 2000, Conference proceedings.
I. Beynum, L. Kapusta, M. Bakker, M. den Heijer, H. Bloom, H. de Walle (2009):
Protective effect of periconceptional folic acid supplements on the risk of congential heart defects: a registry-based case-control study in the northern Netherlands.
European Heart J., 2009 Dec. 1.
A. Czeizel, E. Puhó, Z. Langmar, N. Acs, F. Bánhidy (2010):
Possible association of folic acid supplementation during pregnancy with reduction of preterm birth: a population-based study.
Eur J Obstet Gynecol Reprod Biol., 148(2): 135-40.
M. van Eijsden, L. Smits, G. J. Bonsel et al. (2008):
Association between short interpregnancy intervals and term birth weight: the role of folate depletion 1-3.
Am J Clin Nutr., 88: 147-53.
K. Pietrzik, L. Bailey, B. Shane (2010):
Folic Acid and L-5-Methyltetrahydrofolate
Clin Pharmacokinet., 49(8): 535-548.
Infants & Kids & Adolescents
M. Murphy, J. Fernandez-Ballart, V. Arija, J. Scott, A. Molloy, J. Canals (2007):
Maternal homocysteine at preconception is negatively associated with cognitive achievement in children at 4 months and 6 years of age.
Clin Chem Lab Med. 45(5): 83.
Y. Liu, S. Tomiku, E. Rozoy, S. Simard, L. Bazinet, T. Green, D. Kitts (2012):
Thermal Oxidation Studies on Reduced Folate, L-5-Methyltetrahydrofolic Acid (L-5-MTHF) and Strategies for Stabilization Using Food Matrices.
Journal of Food Science.77(2):C236-C243.
M. Murphy, J. Scott, V. Arija, A. Molloy, J. Fernandez-Ballart (2004):
Maternal Homocysteine before Conception and throughout Pregnancy Predicts Fetal Homocysteine and Birth Weight.
Clin Chem. 50: 1406-1412.
J. Scott (2001):
Methyltetrahydrofolate: The Superior Alternative to Folic acid.
Nutraceuticals in health and disease prevention, 75-90 [Krämer K, Hoppe PP and Packer L, editors].
New York: Marcel Dekker Inc.
P. Verlinde, I. Oey, M. Hendrickx, A. Van Loey, E. Temme (2007):
L-ascorbic acid improves the serum folate response to an oral dose of (6S)-5-methyltetrahydrofolic acid in healthy men.
Eur J Clin Nutr., 62(10):1224-30.
A. Borzutzky, B. Crompton, A. Bergmann, S. Giliani, S. Baxi, M. Martin, E. Neufeld, L. Notarangelo (2009):
Reversible severe combined immunodeficiency phenotype secondary to a mutation of the proton-coupled folate transporter.
Clin. Immunol., 133(3):287-94.
Adults & Elderly
Heart Health
C. Antoniades, C. Shirodaria, N. Warrick, S. Cai, J. de Bono, J. Lee, P. Leeson, S. Neubauer, C. Ratnatunga, R. Pillai, H. Refsum, K. Channon (2006):
5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling. Circulation, 114(11), 1193-201.
B. Venn, T. Green, R. Moser, J. Mann (2003):
Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study.
Am J Clin Nutr, 77(3), 658-62.
H. Bean L.J., et al (2011):
Lack of maternal folic acid supplementation is associated with heart defects in Down syndrome: A report from the National Down Syndrome Project.
Birth Defects Res A Clin Mol Teratol. 2011 Oct;91 (10):885-93.
Y. Lamers, R. Prinz-Langenohl, R. Moser, K. Pietrzik (2004):
Supplementation with (6S)-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women.
Am J Clin Nutr, 79, 473-8.
ZM. Wang et al. (2011):
Folate and risk of coronary heart disease: A meta-analysis of prospective studies.
Nutr Metab Cardiovasc Dis. 2011 Sep 14.
Q. Yang, L. Botto, J. Erickson, R. Berry, C. Sambell, H. Johansen, J. Friedman (2006):
Improvement in stroke mortality in Canada and the United States, 1990 to 2002.
Circulation, 113(10): 1335-43.
J. Spence (2007):
Perspective on the efficacy analysis of the Vitamin Intervention for Stroke Prevention trial.
Clin Lab Med, 45(12): 1582-5.
E. Stroes, E. van Faassen, P. Martasek, P. Boer, R. Govers, T. Rabelink (2000):
Folic acid reverts dysfunction of endothelial nitric oxide synthase.
Circulation Research, 86, 1129-34.
M. Hyndman, S. Verma, R. Rosenfeld, T. Anderson, H. Parsons (2002):
Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function.
Am J Physiol Heart Circ Physiol, 282, H2167-72.
M. Verhaar, R. Wever, J. Kastelein, T. van Dam, H. Koomans, T. Rabelink (1998):
5-Methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
Circulation, 97(3), 237-41.
A. Moens, H. Champion, M. Claeys, B. Tavazzi, P. Kaminski, M. Wolin, D. Borgonjon, L. Van Nassauw, A. Haile, M. Zviman, D. Bedja, F. Wuyts, R. Elsaesser, P. Cos, K. Gabrielson, G. Lazzarino, N. Paolocci, J. Timmermans, C. Vrints, D. Kass (2008):
High-Dose Folic Acid Pretreatment Blunts Cardiac Dysfunction During Ischemia Coupled to Maintenance of High-Energy Phosphates and Reduces Postreperfusion Injury.
Circulation, 117(14):1810-9.
B. Akoglu, M. Schrott, H. Bolouri, A. Jaffari, E. Kutschera, W. Caspary, D. Faust (2007):
The folic acid metabolite L-5-methyltetrahydrofolate effectively reduces total serum homocysteine level in orthotopic liver transplant recipients: a double-blind placebo-controlled study.
Eur J Clin Nutr. 62(6):796-801.
C. Shirodaria, C. Antoniades, J. Lee, C. Jackson, M. Robson, J. Francis, S. Moat, C. Ratnatunga, R. Pillai, H. Refsum, S. Neubauer, K. Channon (2007):
Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease.
Circulation, 115(17): 2262-70.
A. Moens, M. Claeys, F. Wuyts, I. Goovaerts, E. Van Hertbruggen, L. Wendelen, V. Van Hoof, C. Vrints (2007):
Effect of folic acid on endothelial function following acute myocardial infarction.
Am J Cardiol., 99(4): 476-81.
A. de Bree, L. van Mierlo, R. Draijer (2007):
Folic acid improves vascular reactivity in humans: a meta-analysis of randomized controlled trials.
Am J Clin Nutr., 86(3): 610-7.
S. Moat, S. Doshi, D. Lang, I. McDowell, M. Lewis, J. Goodfellow (2004):
Treatment of coronary heart disease with folic acid: is there a future?
Am J Physiol Heart Circ Physiol., 287(1): H1-7.
R. van Etten, E. de Koning, M. Verhaar, C. Gaillard, T. Rabelink (2002):
Impaired NO-dependent vasodilation in patients with Type II (non-insulin-dependent) diabetes mellitus is restored by acute administration of folate.
Diabetologia, 45(7): 1004-10.
S. Doshi, I. McDowell, S. Moat, D. Lang, R. Newcombe, M. Kredan, M. Lewis, J. Goodfellow (2001):
Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?
Arterioscler Thromb Vasc Biol 21(7): 1196-202.
A. Bostom, D. Shemin, R. Gohh, A. Beaulieu, P. Bagley, Z. Massy, P. Jacques, L. Dworkin, J. Selhub (2001):
Treatment of hyperhomocysteinemia in hemodialysis patients and renal transplant recipients.
Kidney Int Suppl. 78: S246-52.
X. Wang, X. Qin, H. Demirtas, J. Li, G. Mao, Y. Huo, N. Sun, L. Liu, X. Xu (2007):
Efficacy of folic acid supplementation in stroke prevention: a meta-analysis.
Lancet, 369(9576): 1876-82.
B-Vitamin Treatment Trialists' Collaboration (2006):
Homocysteine-lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials.
Am Heart J., 151(2): 282-7.
J. Scott (2001):
Methyltetrahydrofolate: The Superior Alternative to Folic acid.
Nutraceuticals in health and disease prevention, 75-90 [Krämer K, Hoppe PP and Packer L, editors].
New York: Marcel Dekker Inc.
O. Hasselwander, W. Hönlein, L. Schweillert, K. Krömer (2000):
5-Methyltetrahydrofolate: The active form of folic acid.
Functional foods 2000, Conference proceedings.
Depression
L. Ginsberg; A. Oubre, Y. Daoud (2011):
L-methylfolate Plus SSRI or SNRI from Treatment Initiation Compared to SSRI or SNRI Monotherapy in a Major Depressive Episode.
Innov Clin Neurosci, 8(1): 19-28.
T. Bottiglieri and E. Reynolds (2000):
Folate in CSF and age. J. Neurol. Neurosurg.
Psychiatry, 69, 562–563.
M. Fava, RC. Shelton, JM. Zajecka (2011):
Evidence for the use of l-methylfolate combined with antidepressants in MDD.
J Clin Psychiatry, 2011 Aug; 72(8): e25.
J. Seppälä et al (2012):
Association between folate intaken and melancholic depressive symptoms. A Finnish population-based study.
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